Unraveling the Causes of Oral Squamous Cell Carcinoma in Non-Habit Patients! Oral squamous cell carcinoma (OSCC) is one of the most prevalent cancers, often linked to tobacco and alcohol use. But what about patients who develop OSCC without these habits? A groundbreaking study explores alternative causes, shedding light on genetic mutations, microbial infections, dental trauma, and oxidative stress. 

 Key Findings:
Genetic Mutations: Novel pathogenic HRAS gene mutations linked to NHOSCC.
Microbial Factors: Significant association between HSV-1 infection and NHOSCC.
Dental Trauma: Regressive changes like sharp or broken teeth increase risk.
Oxidative Stress: Lower antioxidant levels contribute to NHOSCC development. 

Why It Matters: This research challenges traditional beliefs about OSCC causation and opens new doors for prevention, early detection, and treatment strategies. 

Read the Full Study Here: https://link.springer.com/content/pdf/10.1186/s12903-024-05406-z.pdf  

Authors: Mudiyayirakkani Muthusamy, Pratibha Ramani, Paramasivam Arumugam, Parthiban Rudrapathy, Boopathi Kangusamy, Vishnu Priya Veeraraghavan, Selvaraj Jayaraman, Balachander Kannan, Anitha Pandi.

#OralCancer #NHOSCC #MedicalResearch #OralHealth #GeneticMutations #Healthcare #Dentistry #MedicalBreakthrough

https://link.springer.com/content/pdf/10.1186/s12903-024-05406-z.pdf  

Dr Suganya P, Dr Ramya and Dr Sandhya published an article in Q1 Dental Domain Journal. Congrats!

Dr. Deepak Pandiar and Dr. Reshma P K have published an article in the prestigious European Archives of Paediatric Dentistry, a Q1 Dental Domain Journal

We are proud that our Research Professor Dr. Reena Das has Published this Classification and bibliometric analysis of hydrogels in periodontitis treatment: Trends, mechanisms, advantages, and future research directions.

We are proud that our HOD Dr.Pratibha Ramani, our Associate Professor Dr. Deepak Pandiar and our Assistant Professor Dr. Reshma P K has Published this Original article on Molecular profiling of oral epithelial dysplasia and oral squamous cell carcinoma using next generation sequencing.

We are proud that our Associate Dean and Professor and head, Dr. Karthikeyan Ramalingam, our HOD Dr.Pratibha Ramani, and our postgraduate student Dr. Deeksheetha P has Published this Case Report on Traumatic Ulcerative Granuloma With Stromal Eosinophilia (TUGSE): A Case Report.

We are proud that our Associate Dean and Professor and head, Dr. Karthikeyan Ramalingam, our HOD Dr.Pratibha Ramani, and our postgraduate student Dr. Fazulunnisa B has Published this Case report on Inflammatory Paradental Cyst: A Case Report.

We are proud that our Associate Dean and Professor and head, Dr. Karthikeyan Ramalingam, our HOD Dr.Pratibha Ramani, and our postgraduate student Dr. Deeksheetha P has Published this Case report on Sebaceous Hyperplasia of the Face: A Case Report.

We are proud that our Associate Dean and Professor and head, Dr. Karthikeyan Ramalingam, our HOD Dr.Pratibha Ramani, our Professor Dr Gheena S and our postgraduate student Dr. Deeksheetha P has Published this Case report on Trabecular Juvenile Ossifying Fibroma Involving the Maxilla: A Rare Case.

We are proud that our Associate Professor Dr. Deepak Pandiar and our Assistant Professor Dr. Reshma P K has Published this Original article on Immunohistochemical Expression of MDM2, Bcl-2, SATB2 and Ki-67 in Histological Variants of Unicystic Ameloblastoma.

We are proud that our Professor Dr Ramya R has Published this Original article on Optimizing Desmostachya bipinnata-derived platinum nanoparticles for enhanced antibacterial and biofilm reduction.

We are proud that our Associate Professor Dr. Deepak Pandiar, our Assistant Professor Dr. Reshma P K and our postgraduate student Dr. Dharini S has Published this Original article on Evaluation of Anti-inflammatory and Antioxidant Properties of Persea Americana and Syzygium Aromaticum-based Herbal Mouthwash Formulation: An In-vitro Study.

We are Proud that our Professor Dr R Ramya, our Assistant Professor Dr. Sandhya S and Dr. Suganya S and our student Krishna Verma have published this original Research Article on Restoring Enamel Strength: A Knoop Hardness Number Evaluation of Remineralizing Toothpastes.

We are proud that our Associate Dean and Professor and head, Dr. Karthikeyan Ramalingam, our HOD Dr.Pratibha Ramani, and our postgraduate student Dr. Priyadharshini G has Published this Original article on Internal Audit of an Oral Pathology Laboratory: Perspectives on Finances and Operational Management.

We are proud that our Associate Dean and Professor and head, Dr. Karthikeyan Ramalingam, our HOD Dr.Pratibha Ramani, and our postgraduate student Dr. Neha Kannan has Published this Case report on Mucocele of the Lower Lip and Its Surgical Management.

We are proud that our Associate Dean and Professor and head, Dr. Karthikeyan Ramalingam, our HOD Dr.Pratibha Ramani, and our postgraduate student Dr. Dharini S has Published this Case report on Poorly Differentiated Squamous Cell Carcinoma With Jaw Bone Osteomyelitis and Skin Perforation: A Report of a Rare Clinical Case.

We are proud that our Associate Professor Dr. Deepak Pandiar has Published this Mini article on Rodent models for oral microbiome research: considerations and challenges- a mini review.

We are proud that our HOD Dr.Pratibha Ramani, our Associate Professor Dr. Deepak Pandiar and our Assistant Professor Dr. Reshma P K has Published this Original article on The Evaluation of Tumor Budding in Oral Squamous Cell Carcinoma Arising in the Background of Oral Submucous Fibrosis.

We are proud that our Associate Dean and Professor and head, Dr. Karthikeyan Ramalingam has Published this Original article on Use of the Hospital Anxiety and Depression Scale in Patients with Oral Lichen Planus: An Institutional Experience.

We are proud that our Associate Dean and Professor and head, Dr. Karthikeyan Ramalingam has Published this Original article on Evaluating the Efficacy of Actinidia deliciosa (Kiwi Fruit) Extract in Inhibiting Pseudomonas aeruginosa Biofilm Formation: An In Vitro Study With Therapeutic Implications.